Point-of-Care Webinar Series
Watch: It's Time to Clear the Fog About Kidney Function Testing—July 24, 2019
This webinar will cover the pros and cons of both the older and newer tests for acute and chronic renal disease, including creatinine, measured and estimated GFR (glomerular filtration rate), cystatin C, NGAL (neutrophil gelatinase-associated lipocalin), KIM (kidney injury molecule), and IGFBP7 (insulin-like growth factor binding protein, a cell-cycle arrest molecule). It will also discuss how these markers indicate nephron loss, decreased glomerular filtration, and/or renal tubular/cellular damage.
Topics:
Learning Objectives:
This basic level complimentary webinar is produced by Whitehat Communications. Whitehat Communications is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program.
About the Speaker:
Topics:
- The underappreciated value of creatinine measurements, especially serial measurements.
- The significant shortcomings of measured GFR.
- The true meaning of the eGFR and why there is such a large variation between the measured GFR and the eGFR.
- The time course of rises and falls of creatinine, cystatin C, NGAL, and KIM in acute kidney diseases.
- The problems with categorizing kidney disease by measured GFR and the potential benefit of including urine albumin/protein in the kidney disease stage categories.
Learning Objectives:
- Describe the basic functions of the glomeruli and tubules in handling creatinine, cystatin C, and water.
- Discuss the conditions associated with acute and chronic kidney diseases.
- Inspect how creatinine is used in diagnosing and monitoring acute and chronic kidney diseases.
- Review the time course of responses to acute kidney injury for NGAL, KIM, cystatin C, and creatinine.
- Analyze why clearance measurements of GFR vary greatly from serum measurements of creatinine or cystatin C.
- Explain how serum creatinine, creatinine clearance, cystatin C, and NGAL respond to nephron damage or changes in glomerular filtration.
- Assess why the addition of urine albumin will help to minimize false positive eGFR results in a large segment of the population.
This basic level complimentary webinar is produced by Whitehat Communications. Whitehat Communications is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program.
About the Speaker:
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John Toffaletti, Ph.D.
John Toffaletti received a BS from the University of Florida, Gainesville, and followed this with training in clinical chemistry at the University of North Carolina at Chapel Hill, where he earned a Ph.D. in biochemistry. Toffaletti then completed a postdoctoral fellowship in clinical chemistry at Hartford Hospital in Connecticut. Since completing these programs in 1979, Toffaletti has worked in the Clinical Laboratories at Duke University Medical Center, where he is now Professor of Pathology and Director of the Blood Gas Laboratory, the Clinical Pediatric Laboratory, and several outpatient laboratories. He is also the Chief of Clinical Chemistry at the Durham VA Medical Center. He has written or presented numerous workshops, books, study guides, chapters, and seminars on the interpretation of blood gas, co-oximetry, ionized calcium, magnesium, lactate, and renal function tests. Toffaletti’s research interests include sample collection, analysis, and clinical use of these tests. His outside interests include cycling; in fact, Toffaletti has a patent for a novel, ergonomic road bike handlebar. Another interest is the piano. After nearly 40 years of not playing, Toffaletti started playing the piano again about four years ago and now regularly plays the Steinway & Sons piano at the Duke Cancer Center. |
Orchard Software is a proud sponsor of this P.A.C.E®-accredited opportunity on behalf of
Whitehat Communications
We thank the Ohio Point-of-Care Network for their commitment to supporting continuing education.
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